Chronopharmacology of simvastatin on hyperlipidaemia in high‐fat diet‐fed obese mice
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متن کاملDouble-blind comparative clinical trial of Abana and Simvastatin in Hyperlipidaemia
INTRODUCTION Nikolai Anichkov first proposed a link between cholesterol and atherosclerosis in 1912 1 . Decades later observational studies have established hyperlipidaemia as an independent risk factor for coronary artery disease. It is now proved that hyperlipidaemia is an independent risk factor for ischemic stroke. Additional evidences from the prospective studies have shown the relationshi...
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OBJECTIVE To study the effect of simvastatin on picrotoxin-induce seizures in mice in order to understand the impact of gabaergic system on neuronal cell death. METHODS The study was held between July and September 2011, at the Karadeniz Technical University in Trabzon, Turkey. Balb/c mice weighting 20-40g were randomly selected and divided into five groups of six each. The first group was de...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2020
ISSN: 1582-1838,1582-4934
DOI: 10.1111/jcmm.15709